Cyclophosphamide definition of cyclophosphamide by. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. The alkylated metabolites of ifosfamide have been shown to interact with dna. Although this shows a high risk of drug interactions in cancer patients. Incidence and prevention of bladder toxicity from cyclophosphamide. Cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. Effects of ketoconazole on cyclophosphamide metabolism.
Cyclophosphamide is often used for 36 months put a disease into remission. The chemical name for cyclophosphamide is 2 h1,3,2oxazaphosphorin2amine, n,nbis2chloroethyltetrahydro, 2oxide, monohydrate. Cyclophosphamide monohydrate bulk package sigmaaldrich. Cyclophosphamide has a molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Cyclophosphamide is a medicine that kills cancer cells but, as a result, also. Sections or subsections omitted from the full prescribing information are. Cytoxan cyclophosphamide for injection, usp cytoxan tablets cyclophosphamide tablets, usp description cytoxan cyclophosphamide for injection, usp is a sterile white powder containing cyclophosphamide monohydrate. When cyclophosphamide is included in combined cytotoxic regimens, it may be necessary to reduce the dose of cyclophosphamide as well as that of the other drugs. It is also used in selected cases of biopsy proven minimal change nephrotic syndrome in children. Cyclophosphamide for injection, usp, is a chemotherapy agent used to treat certain types of cancer in adults and pediatric patients. A healthcare provider will give you this medication. Ns bolus to achieve urine output prior to infusion. Cyclophosphamide injectable solution is a prescription medication used to treat many types of cancer.
Throughout this leaflet, cyclophosphamide tablets 50 mg will be. Pdf cyclophosphamide is an extensively used anticancer and. Find patient medical information for cyclophosphamide oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The chemical name for cyclophosphamide is 2 bis 2chloroethylaminotetrahydro2 h 1,3,2oxazaphosphorine 2oxide monohydrate. Cyclophosphamide is a white crystalline powder with the molecular formula c 7 h 15 cl 2 n 2 o 2 p h 2 o and a molecular weight of 279. Cyclophosphamide is soluble in water, saline and ethanol. Cyclophosphamide is a cytotoxic drug or anticancer drug. Cytoxan cyclophosphamide for injection, usp cytoxan. Cyclophosphamide is biotransformed principally in the liver to active alkylating metabolites by a mixed function microsomal.
Cyclophosphamide side effects, warnings, dosage, and more. Sandoz launches first generic version of cyclophosphamide. Afterwards, a medication that may be less potent with fewer side effects is used to maintain the disease under control. Proposal for the inclusion of mesna world health organization. Cyclophosphamide fda prescribing information, side. Pdf 637 kb email article add to my reading list export citation create citation alert. Concepts searched were dosing of cyclophosphamide in.
Cyclophosphamide definition is an immunosuppressive and antineoplastic agent c7h15cl2n2o2p used especially in the treatment of lymphomas and some leukemias. Highdose cisplatin and cyclophosphamide with glutathione in the. The most common adverse reactions in chemotherapyinduced nausea and vomiting in. Cytoxan tablets cyclophosphamide tablets, usp are for oral use and contain 25 mg or 50 mg cyclophosphamide anhydrous. The treatment of intact cell nuclei may also result in the formation of dnadna crosslinks. Mesna, sold under the brand name mesnex among others, is a medication used in those taking cyclophosphamide or ifosfamide to decrease. Highdose cisplatin and cyclophosphamide with glutathione in the treatment of advanced ovarian cancer. Each capsule for oral administration contains 25 mg or 50 mg cyclophosphamide anhydrous, usp and the following inactive ingredients. In vitro incubation of dna with activated ifosfamide has produced phosphotriesters.